Sima Sistani is an Adjunct Professor at Duke University, a position she has held since 2025. She also serves on the Board of Directors for Best Buy, a role she began in 2023.

Prior to her current roles, Sistani was the Chief Executive Officer at WW from March 2022 to October 2024. She cofounded and served as CEO of Houseparty from May 2015 to March 2022, a company that later became part of Epic Games. Her career also includes a tenure as Head of Media at Tumblr from January 2014 to May 2015.