Matthew Del Negro is an American actor born in Mount Kisco, New York. He graduated from John Jay High School in Cross River, New York in 1990 and later from Boston College, where he played Division I lacrosse and earned a Bachelor of Arts in English Language and Literature. After college, Del Negro began studying acting, leading to early appearances in commercials and independent films.

Del Negro gained recognition for his role as Brian Cammarata on The Sopranos.