Karen Friedman Agnifilo is an American attorney and legal commentator. She earned her undergraduate degree from the University of California, Los Angeles in 1988 and her Juris Doctor from Georgetown University Law Center in 1992.
Friedman Agnifilo spent over two decades in public service within New York City's criminal justice system. From 2014 to 2021, she held the position of Chief Assistant District Attorney under Manhattan District Attorney Cyrus Vance Jr.